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HPE ProLiant DL385 Gen10 vs. Gen10 Plus vs. Gen11: Technical Comparison and Use Cases

Among the latest versions of the HPE DL385, the Gen10 and Gen10 Plus are budget-friendly options widely available on the refurbished market, offering excellent value for most workloads. The Gen11 is more expensive but ideal for advanced workloads requiring the latest technology. Choose based on your budget and specific needs.


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Technical Comparisons: HPE ProLiant DL385 Gen10 vs. Gen10 Plus vs. Gen11

Feature
HPE DL385 Gen10
HPE DL385 Gen10 Plus
HPE DL385 Gen11

Processor Support

AMD EPYC 7000 Series

AMD EPYC 7002 Series

AMD EPYC 9004 Series

Memory

Up to 4 TB DDR4 (2666 MT/s)

Up to 4 TB DDR4 (3200 MT/s)

Up to 8 TB DDR5 (4800 MT/s)

Storage

Up to 24 SFF or 12 LFF drives

Up to 24 SFF or 12 LFF drives

Up to 24 NVMe or 12 LFF drives

PCIe Slots

6 PCIe 3.0

6 PCIe 4.0

6 PCIe 5.0

Networking

2x 1GbE; FlexibleLOM for 10GbE/25GbE

2x 1GbE; FlexibleLOM for 10GbE/25GbE

Dual 10GbE; FlexibleLOM for up to 100GbE

Power Efficiency

Up to 94%

Up to 96%

Up to 98%

GPU Support

Up to 2 double-width GPUs

Up to 4 double-width GPUs

Up to 6 double-width GPUs

Management Software

iLO 5

iLO 5 Advanced

iLO 6

Security Features

Silicon Root of Trust

Silicon Root of Trust

TPM 2.0, Secure Boot, Silicon Root of Trust

High-resolution image of HPE ProLiant DL385 Gen10, Gen10 Plus, and Gen11 servers side by side, showcasing their key features, including AMD EPYC processors, DDR4 and DDR5 memory support, PCIe 3.0, 4.0, and 5.0 slots, advanced GPU capabilities, and enhanced storage options such as NVMe and LFF drives. The servers are ideal for a range of workloads, from legacy applications to cutting-edge AI, ML, and HPC environments. This image emphasizes the sleek design and robust build quality of HPE ProLiant servers available through server-parts.eu, your trusted source for refurbished enterprise IT equipment. Perfect for IT decision-makers looking to optimize infrastructure for cost-effective upgrades or future-proofed performance. Keywords: HPE ProLiant DL385, Gen10, Gen10 Plus, Gen11, AMD EPYC processors, DDR5 memory, NVMe storage, PCIe slots, GPU support, AI servers, HPC workloads, server-parts.eu, refurbished IT hardware, enterprise infrastructure, budget-friendly servers, IT hardware solutions.

Use Cases: HPE ProLiant DL385 Gen10 vs. Gen10 Plus vs. Gen11


Understanding the strengths of each generation helps identify the best fit for specific workloads and organizational needs.


HPE DL385 Gen10: Cost-Effective Reliability


The Gen10 is ideal for businesses with tight budgets that need a dependable solution for standard workloads. It supports legacy applications and virtualization environments, making it a great choice for:


  • Legacy environments where moderate compute power is sufficient.

  • Backup servers or disaster recovery solutions.

  • Organizations seeking cost-effective upgrades to expand existing Gen10 fleets.


The Gen10’s broad compatibility ensures seamless integration with older systems, especially for businesses that don’t require high-speed NVMe storage or advanced AI workloads.


HPE DL385 Gen10 Plus: Balanced Performance Upgrade


The Gen10 Plus strikes a balance between price and performance. It offers faster PCIe 4.0 connectivity, better NVMe support and increased memory capacity, making it an excellent choice for:


  • Businesses transitioning from Gen10 hardware needing modest performance boosts.

  • Virtualization environments with growing performance demands.

  • Storage-heavy hybrid cloud deployments utilizing NVMe drives.


The Gen10 Plus provides noticeable improvement in memory speed and storage capabilities without the premium cost of newer technologies like DDR5 or PCIe 5.0.


HPE DL385 Gen11: Future-Proofed Performance


The Gen11 is the cutting-edge option for organizations investing in long-term infrastructure. With support for DDR5 memory, PCIe 5.0 and up to six GPUs, it excels in compute-intensive scenarios:


  • AI/ML and HPC workloads requiring powerful GPU power.

  • High-performance enterprise databases and applications needing extreme scalability.

  • Businesses planning for future growth and adopting modern cloud-native architectures.


Advanced security features like TPM 2.0 and improved energy efficiency (up to 98%) make the Gen11 a strategic choice for enterprises seeking sustainability and data protection.


When to Choose Each Model: HPE ProLiant DL385 Gen10 vs. Gen10 Plus vs. Gen11


The decision between Gen10, Gen10 Plus, and Gen11 ultimately depends on your organization’s requirements:

Scenario

Recommended Model

Tight budgets with no need for the latest tech

HPE DL385 Gen10

Moderate upgrades with better NVMe performance

HPE DL385 Gen10 Plus

Cutting-edge AI, HPC, or future-proofing needs

HPE DL385 Gen11

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