HPE ProLiant DL380 Gen11 vs Gen12 Comparison - What’s the Difference?
- server-parts.eu server-parts.eu

- Feb 15
- 3 min read
Updated: Feb 17
The HPE ProLiant DL380 series has long been a staple in enterprise environments, known for its reliability, scalability, and performance. With the introduction of the HPE ProLiant Compute DL380 Gen12, IT professionals are now faced with an important question: how does it compare to the DL380 Gen11?
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HPE ProLiant DL380 Gen11 vs Gen12 Comparison - What's the Difference?
The HPE ProLiant Compute DL380 Gen12 improves on the Gen11 with next-gen Intel Xeon processors, higher memory bandwidth, and PCIe 5.0 support for faster storage and GPU performance. It also features better power efficiency, enhanced security, and improved remote management, making it a stronger choice for modern AI, cloud, and HPC workloads.
HPE ProLiant DL380 Gen11 vs Gen12: Core Architecture and Processor Support
Key Differences between HPE ProLiant DL380 Gen11 and Gen12
Gen12 introduces support for Intel Xeon 6th Gen processors, bringing significant performance and efficiency improvements, particularly for AI and HPC workloads.
Higher cache allocation allows for improved processing efficiency and reduced latency.
Increased NUMA nodes improve multi-threaded application performance and workload distribution.
Higher power draw per CPU (TDP), requiring optimized thermal management solutions.
HPE ProLiant DL380 Gen11 vs Gen12: Memory Performance and Capacity
Key Differences between HPE ProLiant DL380 Gen11 and Gen12
Gen12 increases max memory capacity to 8TB using CXL-based memory expansion, eliminating traditional Optane Persistent Memory support.
Enhanced memory bandwidth, allowing for better performance in memory-intensive applications such as AI/ML workloads.
HPE ProLiant DL380 Gen11 vs Gen12: Storage and Expandability
Key Differences between HPE ProLiant DL380 Gen11 and Gen12
Gen12 adds Compute Express Link (CXL) storage support, allowing for direct CPU-to-storage access without traditional bottlenecks.
Introduction of NVMe over Fabrics (NVMeoF) and RDMA for high-speed networking storage solutions.
HPE ProLiant DL380 Gen11 vs Gen12: Connectivity and Expansion
Key Differences between HPE ProLiant DL380 Gen11 and Gen12
Gen12 introduces NVLink and RDMA support, enabling faster GPU communication and low-latency networking for AI and HPC workloads.
Same PCIe 5.0 slots and OCP 3.0 networking, but Gen12 optimizes expansion lanes for improved high-speed connectivity.
HPE ProLiant DL380 Gen11 vs Gen12: Power and Cooling
Key Differences between HPE ProLiant DL380 Gen11 and Gen12
Dynamic power scaling introduced in Gen12, allowing the system to optimize power consumption dynamically based on workload requirements.
Enhanced liquid cooling, optimized for high-performance compute tasks, reducing thermal throttling risks.
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