HPE ProLiant DL380 Gen10 Server Types, Specs, and Technical Comparison

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Jul 3
3 min read

The HPE ProLiant DL380 Gen10 is a dual-socket 2U rack server built for modern enterprise workloads. This generation introduced support for 1st and 2nd Gen Intel Xeon Scalable processors, DDR4 memory, PCIe 3.0, and improved I/O flexibility.

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For IT professionals planning infrastructure upgrades or new deployments, understanding the DL380 Gen10 variants is very important. This article compares all available types, including the standard configurations (SFF, LFF, NVMe) and GPU-supported models.

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HPE ProLiant DL380 Gen10 Servers: Core Architecture Overview

All DL380 Gen10 servers share the same core platform capabilities:

HPE ProLiant Gen10 Processors: Dual 1st or 2nd Gen Intel Xeon Scalable CPUs, up to 28 cores per CPU.
HPE ProLiant Gen10 Memory: Up to 3.0 TB DDR4 with 24 DIMM slots (12 per CPU); or up to 6.0 TB with Persistent Memory (HPE DC PM).
HPE ProLiant Gen10 Expansion: Up to 8 PCIe Gen3 slots across primary, secondary, and tertiary risers.
HPE ProLiant Gen10 Security and Management: HPE iLO 5 with silicon root of trust and advanced runtime firmware protection.

Standard HPE ProLiant DL380 Gen10 Server Configurations

HPE ProLiant Gen10 SFF (Small Form Factor) Model – 2.5" Drives

Base: 8 front SFF bays.
Expandable: Up to 24 front SFF + 6 rear SFF = 30 total SFF drives.
Drive Support: SAS, SATA, and NVMe (via optional backplanes).
Use Case: Balanced workloads; ideal for virtualization, mixed storage needs, and general-purpose applications.

HPE ProLiant Gen10 LFF (Large Form Factor) Model – 3.5" Drives

HPE ProLiant Gen10 Base: 12 front LFF bays.
HPE ProLiant Gen10 Expandable: Up to 4 mid-plane LFF + 3 rear LFF + 2 rear SFF = up to 19 LFF and 2 SFF.
HPE ProLiant Gen10 Drive Support: Primarily SAS/SATA HDDs or SSDs.
HPE ProLiant Gen10 Use Case: Capacity-heavy roles such as backup, data lakes, and large-volume storage.

HPE ProLiant Gen10 NVMe Model – All-Flash NVMe

HPE ProLiant Gen10 Options: Up to 20 front-accessible NVMe bays (Gen3).
HPE ProLiant Gen10 Drive Support: PCIe Gen3 NVMe drives.
HPE ProLiant Gen10 Use Case: High-performance flash workloads like VDI, real-time analytics, and NVMe-based SDS environments.

GPU Support in DL380 Gen10 Servers

Unlike Gen11, which introduced a separate DL380a variant, the DL380 Gen10 integrates GPU support across standard models:

HPE ProLiant Gen10 GPU Capacity: Up to 3 double-wide or 5 single-wide GPUs.
HPE ProLiant Gen10 Cooling and Power: Requires high-performance fans and optional PSU configurations for GPU use.
HPE ProLiant Gen10 Use Case: AI/ML workloads, HPC, and GPU-intensive computing environments.

HPE ProLiant DL380 Gen10 Server Comparison Table

Feature	DL380 Gen10 SFF	DL380 Gen10 LFF	DL380 Gen10 NVMe
Processor Support	2x 1st/2nd Gen Xeon	Same	Same
Max Memory	3.0 TB DDR4 / 6.0 TB w/ PM	Same	Same
Front Drive Bays	8–24 SFF, up to 30 total	Up to 19 LFF + 2 SFF	Up to 20 NVMe
GPU Support	Up to 3 DW / 5 SW GPUs	Same	Same
PCIe Expansion	Up to 8 PCIe 3.0 slots	Same	Same
Power Supplies	2 (500W–1600W)	Same	Same
Ideal Use Case	Virtualization, mixed	Archive, backup	NVMe flash workloads

Note: GPU support is integrated—there is no dedicated “a” version like the Gen11 DL380a.

How to Choose the Right HPE ProLiant DL380 Gen10 Server

HPE ProLiant Gen10 SFF: Great all-rounder. Choose this if you want storage flexibility with performance.
HPE ProLiant Gen10 LFF: Best for pure capacity at lower cost per TB.
HPE ProLiant Gen10 NVMe: Choose for NVMe speed and density; ideal for all-flash environments.
HPE ProLiant Gen10 GPU Support: Integrated into standard models—add GPUs only if needed, and ensure proper cooling.

Final Thoughts – HPE ProLiant DL380 Gen10 Servers

Each DL380 Gen10 configuration is built for a different type of IT workload. Whether you're building a virtualized environment, planning a storage-heavy deployment, or exploring AI and GPU computing, there's a matching DL380 Gen10 model. Knowing the strengths and limits of each ensures better planning and smarter infrastructure decisions.